If executed properly, hex throwers won’t even be a problem. However, this layout still uses EV2’s reflect beams to negate hex throwers. Mobs are sieved through the spawn AOE and the stragglers are zapped to death by the LSA field. A sample ascension build is shown below. Only the relevant ascension points shown for brevity. All shards are maxed.
Ascension Recommended: 200 (67/67/66)

Monk (82/81/81)
Defense. Full Defense Speed, 60 Flame Aura Power, 1 LSA Power.
Utility. Full Defense Crit Chance, 21 FA Gambit.

• Flame Aura: 15.2k Mark
  • Deadly Strikes
  • Destruction
  • Defensive Critical Damage
• Lightning Strikes Aura: 13.7k Mark
  • Defense Rate
  • Destruction
  • Defensive Critical Damage
• Sky Guard Tower: 13.5k Totem
  • Vampiric Empowerment
  • Fortification
  • Defensive Critical Damage

Huntress (82/81/81)
Defense. Full Defense Speed, 61 PDT Power.
Utility. Full Defense Crit Chance, 20 Defense Crit Damage, 41 PDT Gambit.

• Poison Dart Tower: 14.8k Medallion
  • Explosive Poison
  • Defense Rate
  • Destruction

Series EV2 (0/81/81)
My EV2 Builder has absolutely no ascension points in Reflect Beam.
Utility. Full Defense Crit Chance. 46 Defense Crit Damage.

• Reflect Beam: 12.8k Totem
  • Fortification

Mystic (82/81/81)
Defense. Full Viper’s Fang Health.
Utility. 1 Snaking Sand Stun Duration. (If you have 0 points on it, that’s fine too.)

• Viper’s Fangs (Wall): 15.4k Totem
  • Fortification
  • Explosive Guard
  • Shielding Guard
• Snaking Sands: 14.5k Mark
  • Shards can be any – it’s only used for the slow and the stun.